Crystallographic scientific tests of similar hydroxamic acid inhibitors certain to histone deacetylase active web sites reveal which the ortho-methyl team would generate unfavorable steric clashes with amino acid residues lining the enzyme's binding pocket [11]. The spatial constraints imposed by this methyl substitution successfully block the hydroxamic acid from acquiring the appropriate orientation necessary for zinc coordination and enzyme inhibition [18].

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Specified hydroxamate-based HDAC inhibitors have demonstrated neuroprotective effects against oxidative tension induced by H₂O₂.

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Chemical Reactions That commonly involve the development of hydroxamic acid groups, that are essential for its inhibitory action from histone deacetylase six. The compound's synthesis might contain the reaction of suitable amines with carboxylic acids under certain conditions to produce the desired hydroxamic acid framework.

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